Mandy Moore | Grey's Anatomy
- Genre: Medical drama, Romantic drama, Ensemble drama, Dark comedy
- Created by: Shonda Rhimes
- Narrated by: Ellen Pompeo and various others
- Theme music composer: Psapp
- Opening theme: "Cosy in the Rocket"
- Ending theme: "Cosy in the Rocket" (instrumental)
- Composer: Danny Lux
- No. of seasons: 19
- No. of episodes: 420
- Executive producers: Shonda Rhimes, Ellen Pompeo, Allan Heinberg, Andy Reaser, Betsy Beers, Debbie Allen, James D. Parriott, Jeannine Renshaw, Jeff Rafner, Joan Rater, Kent Hodder, Krista Vernoff, Mark Gordon, Mark Wilding, Marti Noxon, Meg Marinis, Peter Horton, Rob Corn, Stacy McKee, Steve Mulholland, Tony Phelan, William Harper, Zoanne Clack
- Producers: Ann Kindberg, Austin Guzman, Elisabeth R. Finch, Gabrielle G. Stanton, Harry Werksman, James E. Williams, Jeff Rafner, Linda Klein, Lisa Taylor, Mark Foreman, Meg Marinis, Michael Metzner, Mimi Schmir, Peter Nowalk, Sara E. White, Stacy McKee, Tammy Ann Casper, Tia Napolitano, William Harper, Zoanne Clack
- Cinematography: Herbert Davis, Tim Suhrstedt, Jeffrey Jur
- Editors: Susan Vaill, David Greenspan, Edward Ornelas, Justin Chinn, Briana London, Sarah Boyd, Stacy Katzman, Brandi Bradburn, Bjorn Myrholt
- Running time: 43–53 minutes
- Production companies: Shondaland, Entertainment One, ABC Signature, Trip The Light
- Original network: ABC
- Original release: March 27, 2005 – present
A drama centered on the personal and professional lives of surgical interns and their supervisors.
"Sanctuary"
The hospital is hit with an unprecedented crisis: a shooter is in the hospital, and making the hospital go into a lockdown. Meredith discovers that she is pregnant, while Cristina breaks up with Owen after he can't decide between her and Teddy. The shooter, Gary Clark, kills Reed Adamson and seriously wounds Alex, which leads to Lexie and Mark trying to save him. Owen and Teddy risk their lives to move their patient to the ICU. Bailey must try to save Charles with the help of her patient Mary (Mandy Moore) after he is shot, while Derek is confronted by Gary Clark, who shoots him after being interrupted by April.
"Death And All His Friends"
With the crisis unfolding, each character is put through extreme trials and tribulations. Cristina is put under pressure to save Derek, who has been shot. Arizona and Callie reinstate their relationship after Callie decides she doesn't want to have a baby if it means she can't be with Arizona, while Arizona decides she doesn't want to prevent Callie from becoming a mother. Owen realizes he loves Cristina and chooses her over Teddy, while Lexie confesses her feelings to Alex. Bailey tries to save Charles, who has been shot by Gary, but ultimately fails due to the police shutting down the hospital elevators. Gary walks into the OR where Cristina and Jackson are trying to save Derek and tells them at gunpoint to stop operating on him. Jackson disconnects the heart monitor from Derek so it looks like he is flatlining. Gary is fooled into thinking Derek has died and leaves. Unfortunately, Meredith is also fooled and the shock of thinking her husband is dead is enough to trigger a miscarriage. Gary ends up in the room his wife died in with one bullet left. Webber, realizing Gary's actions are partly his fault due to his mishandling his wife's illness, enters the room. Gary admits that his plan was to save enough bullets to kill Webber with one and himself with another, but now he doesn't know what to do. Webber says he has a choice: either kill him and go to prison or shoot himself and be reunited with his wife. Outside, a gunshot is heard and Webber grimly walks out.
"These Arms of Mine"
A documentary film crew visits the hospital six months after the shooting to document the recovery process of doctors and patients. Mary Portman returns to the hospital to have Bailey perform her surgery. Meanwhile, Derek and other surgeons prepare to do a double arm transplant on a logger who lost his arms in an accident four years previously. Alex treats a young girl who is slowly dying that no other doctor has been able to cure up to now. Alex, however, looks for an alternative cure. Derek is able to operate and save the logger. In the end, Alex manages to find a treatment that involves the growth of a trachea in vitro and saves the life of the girl. After Arizona receives an elite medical grant based on a proposed project in Africa, she and Callie decide to go together. Although the surgery went well, Mary does not wakeup and Bailey is devastated.
"That's Me Trying"
Cristina is left alone to watch an ill patient while Teddy goes to retrieve his organ transplant. Owen puts the residents through a rigorous trauma certification drill. Mark and Lexie perform surgery on a woman who wants butt implants. Callie and Arizona prepare for their trip to Africa, but at the airport, Arizona says she does not want Callie to go, as she has been so ambivalent. Arizona ends the relationship. Cristina quits, explaining she doesn't want to be a surgeon anymore. Bailey tries to deal with the trauma of losing Mary.

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